Prof. Dr. Eicke Latz

Director, Institute of Innate Immunity

Medical Faculty, University of Bonn

Sigmund-Freud-Str. 25, 53105 Bonn

Phone: 0228-287-51223,  Fax: 0228-287-51221

Honors & Awards (Selection)                     

2004                     Federation of Clinical Immunology Societies (FOCIS) Award

2001                     Postdoctoral Training Grant of the German Academic Exchange Program (DAAD)

2000                     Scholarship of the Japanese Society for Endoscopy

2000                     Award of the Japanese Society of Surgery, Tokyo National Cancer Center

Selected Publications  

• Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. (2010).NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals early in disease. Nature464, 1357-61

• Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE; Waggoner L, Vanaja SK, Monks BG, Ganesan S, Latz E, Hornung V, Vogel SN, Szomolanyi-Tsuda E, Fitzgerald KA. (2010). The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol11, 395-402.

• Bauernfeind, FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E.(2009). Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol183, 787-791

• Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E. (2008). Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol9, 847-856.

• Latz E,Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ,Lamphier MS., Duprex WP, Espevik T, Golenbock DT. (2007). Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol8, 772-779.