Prof. Dr. Gunther Hartmann
Director, Institute for Clinical Chemistry and Clinical Pharmacology
Medical Faculty, University of Bonn
Sigmund-Freud-Str. 25, 53105 Bonn
Phone: 0228-287-16080, Fax: 0228-287-19822
Awards and Honors (Selection)
2000 Paul-Martini-Award
2004 Biofuture Award, BMBF
2004 Ludwig-Heilmeyer-Award
2007 Wilhelm Vaillant Award
2010 GoBio Award, BMBF
Selected Publications
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Hornung V., Guenthner-Biller M., Bourquin C., Ablasser A., Schlee M., Uematsu S., Noronha A., ManoharanM.,Akira S., de Fougerolles A., Endres S., HartmannG.(2005). Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med, 11, 263-270
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Hornung V., Ellegast J., Kim S., Brzozka K., Jung A., Kato H., Poeck H., Akira S., Conzelmann K. K., SchleeM.,Endres S., Hartmann G. (2006). 5'-Triphosphate RNA is the ligand for RIG-I. Science, 314:994-997.
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Poeck H., Besch R., Maihoefer C., Renn M., Tormo D., Morskaya S. S., Kirschnek S., Gaffal E., Landsberg J.,Hellmuth J., Schmidt A., Anz D., Bscheider M., Schwerd T., Berking C., Bourquin C., Kalinke U., Kremmer E., Kato H., Akira S., Meyers R., Hacker G.,. Neuenhahn M., Busch D., Ruland J., Rothenfusser S., Prinz M., Hornung V.,Endres S., Tuting T., Hartmann G. (2008). 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med, 14, 1256-1263
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Schlee M., Roth A., Hornung V., Hagmann C. A., Wimmenauer V., Barchet W., Coch C.,. Janke M, Mihailovic A.,Wardle G., Juranek S., Kato H., Kawai T., Poeck H., Fitzgerald K. A., Takeuchi O., Akira S., Tuschl T., Latz E., Ludwig J., Hartmann G.(2009). Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity, 31, 25-34
- Poeck H., Bscheider M., Gross O., Finger K., Roth S., Rebsamen M., Hannesschlager M., SchleeM.,Rothenfusser S., Barchet W., Kato H., Akira S., Inoue S., Endres S., Peschel C., Hartmann G. °,Hornung V°,Ruland J.° (2010). Recognition of RNA virus by RIG-I results in activation of CARD9 andinflammasome signaling for interleukin 1 beta production. Nat Immunol, 11, 63-69. (°equally contributed)
