Prof. Dr. Jens C. BrĂ¼ning



Prof. Dr. J. Brüning

Director, Department of Mouse Genetics and Metabolism,  Institute for Genetics

Faculty of Mathematics and Natural Sciences, University of Cologne

Zülpicher Str. 47 a, 50674 Cologne

Phone: 0221-470-2467, Fax: 0221-470-5185


Honors & Awards (Selection)

2001                     Ernst and Berta Scharrer Award, German Society of Endocrinology (DGE)

2005                     Wilhelm-Vaillant-Award 2005 of the Wilhelm-Vaillant-Foundation in Munich

2006                     Lesser-Loewe-Award of the Lesser Loewe Foundation in Mannheim

2005                     Wilhelm Gottfried Leibniz-Award of the German Research Council (DFG)

2008                     Minkowski-Award of the European Association for the Study of Diabetes (EASD)

2009                     Ernst Jung-Award of the Ernst Jung-Foundation, Hamburg


Selected Publications

  • Wunderlich FT, Ströhle P, Könner AC, Gruber S, Tovar S, Ringeisen G, Brüning JC. (2010). Interleukin-6-Signaling in liver parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab in press.
  • Mauer J, Chaurasia B, Plum L, Quast T, Hampel B, Blüher M, Kolanus W, Kahn CR, Brüning JC. (2010). Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance. PLoS Genet 6; 6:e1000938.
  • Belgardt BF, Mauer J, Wunderlich FT, Ernst M, Pal M, Spohn G, Brönneke H, Brodesser S, Hampel B, Schauss A, Brüning JC (2010). Hypothalamic and Pituitary JNK1 Signaling Coordinately Regulates Glucose Metabolism. Proc Natl Acad Sci U S A 107, 6028-6033.
  • Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC. (2009). MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10, 249-259. 
  • Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC*, Rüther U* (2009). Inactivation of the Fto gene protects from obesity. Nature 458, 894-898. *communicating authors